Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid

被引：22

作者：

Thomas, C ^{[1
]}

Hübner, H ^{[1
]}

Gmeiner, P ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Pharm & Lebensmittelchem, D-91052 Erlangen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(99)00086-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Subreceptor selectivity tuning of N-(3 -pyrrolidinyl)benzamides leading to the selective dopamine D3 ligand entlh and the derivatives 1g and 1e/entle which preferably recognize human D2 or D4 receptors, respectively, is described. Binding profiles were controlled by both, absolute and relative configuration. The enantiopure target compounds were synthesized from aspartic acid. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：841 / 846

页数：6

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