Hippocampal activation during retrieval of spatial context from episodic and semantic memory

被引:64
作者
Hoscheidt, Siobhan M. [1 ]
Nadel, Lynn [1 ]
Payne, Jessica [2 ]
Ryan, Lee [1 ]
机构
[1] Univ Arizona, Dept Psychol, Tucson, AZ 85721 USA
[2] Univ Notre Dame, Dept Psychol, Notre Dame, IN 46556 USA
关键词
Hippocampus; Medial temporal lobe; Spatial; Episodic; Semantic; MEDIAL TEMPORAL-LOBE; REMOTE AUTOBIOGRAPHICAL MEMORIES; COMMON; RECOGNITION; FMRI; NAVIGATION; PRECUNEUS; KNOWLEDGE; FLUENCY; AMNESIA;
D O I
10.1016/j.bbr.2010.04.010
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学(含古人类学)];
摘要
The hippocampus, a region implicated in the processing of spatial information and episodic memory, is central to the debate concerning the relationship between episodic and semantic memory. Studies of medial temporal lobe amnesic patients provide evidence that the hippocampus is critical for the retrieval of episodic but not semantic memory. On the other hand, recent neuroimaging studies of intact individuals report hippocampal activation during retrieval of both autobiographical memories and semantic information that includes historical facts, famous faces, and categorical information, suggesting that episodic and semantic memory may engage the hippocampus during memory retrieval in similar ways. Few studies have matched episodic and semantic tasks for the degree to which they include spatial content, even though spatial content may be what drives hippocampal activation during semantic retrieval. To examine this issue, we conducted a functional magnetic resonance imaging (fMRI) study in which retrieval of spatial and nonspatial information was compared during an episodic and semantic recognition task. Results show that the hippocampus (1) participates preferentially in the retrieval of episodic memories: (2) is also engaged by retrieval of semantic memories, particularly those that include spatial information. These data suggest that sharp dissociations between episodic and semantic memory may be overly simplistic and that the hippocampus plays a role in the retrieval of spatial content whether drawn from a memory of one's own life experiences or real-world semantic knowledge. Published by Elsevier B.V.
引用
收藏
页码:121 / 132
页数:12
相关论文
共 60 条
[1]
Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration [J].
Addis, Donna Rose ;
Wong, Alana T. ;
Schacter, Daniel L. .
NEUROPSYCHOLOGIA, 2007, 45 (07) :1363-1377
[2]
[Anonymous], 2002, NEUROIMAGE
[3]
[Anonymous], 1983, Canadian Psychology
[4]
Ashburner J, 1999, HUM BRAIN MAPP, V7, P254, DOI 10.1002/(SICI)1097-0193(1999)7:4<254::AID-HBM4>3.0.CO
[5]
2-G
[6]
Pattern separation in the human hippocampal CA3 and dentate gyrus [J].
Bakker, Arnold ;
Kirwan, C. Brock ;
Miller, Michael ;
Stark, Craig E. L. .
SCIENCE, 2008, 319 (5870) :1640-1642
[7]
Double dissociation of function within the hippocampus: A comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions [J].
Bannerman, DM ;
Yee, BK ;
Good, MA ;
Heupel, MJ ;
Iversen, SD ;
Rawlins, JNP .
BEHAVIORAL NEUROSCIENCE, 1999, 113 (06) :1170-1188
[8]
Barsalou L.W., 1988, REMEMBERING RECONSID, P193, DOI [DOI 10.1017/CBO9780511664014.009, 10.1017/CBO9780511664014.009]
[9]
Successful recollection of remote autobiographical memories by amnesic patients with medial temporal lobe lesions [J].
Bayley, PJ ;
Hopkins, RO ;
Squire, LR .
NEURON, 2003, 38 (01) :135-144
[10]
Failure to acquire new semantic knowledge in patients with large medial temporal lobe lesions [J].
Bayley, PJ ;
Squire, LR .
HIPPOCAMPUS, 2005, 15 (02) :273-280