Hepatitis B virus escape mutants induced by antiviral therapy

被引：112

作者：

Sheldon, Julie ^{[1
]}

Soriano, Vincent ^{[1
]}

机构：

[1] Hosp Carlos III, Dept Infect Dis, Madrid, Spain

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2008年 / 61卷 / 04期

关键词：

hepatitis B virus; HBV; drug resistance; lamivudine; HBsAg; occult hepatitis; vaccine;

D O I：

10.1093/jac/dkn014

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The hepatitis B virus (HBV) polymerase and envelope genes overlap in such a way that resistance mutations to antiviral agents in the reverse transcriptase gene may affect the antigenicity of the HBV surface antigen. Mutant viruses may escape serological diagnosis using specific anti-HBV surface antigen antibodies, causing occult forms of chronic hepatitis B. Moreover, these HBV strains may evade vaccine protection, representing a public health challenge. Thus, the circulation of HBVs encoding envelope mutations selected by antiviral agents requires close monitoring.

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收藏

页码：766 / 768

页数：3

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