Synthesis of bisfunctionalized-oligopyridines bearing an ester group

被引：27

作者：

Ulrich, G ^{[1
]}

Bedel, S ^{[1
]}

Picard, C ^{[1
]}

Tisnès, P ^{[1
]}

机构：

[1] Univ Toulouse 3, UMR 5068, Lab Synth & Physico Chim Mol Interet Biol, F-31062 Toulouse 4, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 35期

关键词：

Stille cross-coupling; organotin pyridines; bipyridine; terpyridine; radical bromination;

D O I：

10.1016/S0040-4039(01)01195-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 2,2 ' -bipyridine, 1,10-phenantroline and 2,2 ' :6 ' ,2 " -terpyridine substituted by an ethylester function is described. The 5- and 6-methyl-2,2 ' -bipyridines bearing an ethylester group on the 6 ' position as well as the ethyl 6,6 " -dimethyl-2,2 ' :6 ' ,2 " -terpyridine-4 ' -carboxylate moiety were synthesized via a Stille cross-coupling reaction, starting from bromo-picoline building blocks. A radical bromination of the methyl-oligopyridine gave selectively the corresponding benzylic bromide derivatives in fair yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6113 / 6115

页数：3