Neopterin production and tryptophan degradation in humans infected by Streptococcus pyogenes

被引:32
作者
Murr, C
Gerlach, D
Widner, B
Dierich, MP
Fuchs, D
机构
[1] Univ Innsbruck, Inst Med Chem & Biochem, A-6020 Innsbruck, Austria
[2] Univ Jena, Inst Expt Microbiol, D-6900 Jena, Germany
[3] Univ Innsbruck, Inst Hyg, A-6020 Innsbruck, Austria
[4] Ludwig Boltzmann Inst AIDS Res, Innsbruck, Austria
关键词
Streptococcus pyrogenes; neopterin; tryptophan degradation;
D O I
10.1007/s430-001-8023-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Streptococcus pyogenes may cause tonsillitis, scarlet fever and so-called "streptococcal toxic shock-like syndrome" (STSS). These streptococci produce exotoxins which are implicated as superantigens in the pathogenesis of STSS and scarlet fever. Using human peripheral blood-derived mononuclear cells in vitro, such toxins were shown to induce neopterin production and degradation of the amino acid tryptophan to metabolites such as kynurenine by activating indoleamine (2,3)-dioxygenase via interferon-gamma. We investigated the sera of seven patients with streptococcal tonsillitis and of four patients with STSS. Those with STSS showed higher serum neopterin concentrations (median: 152 nmol/l; 95th percentile in healthy controls: 8.7 nmol/l) than those with tonsillitis (median: 12 nmol/l). Similarly, kynurenine to tryptophan ratios were increased in tonsillitis and extremely high in patients with STSS. Highly increased neopterin production and tryptophan degradation in patients with STSS suggest an association between a high degree of T cell activation and the severity of the disease manifestation.
引用
收藏
页码:161 / 163
页数:3
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