Linear assemblies of magnetic nanoparticles as MRI contrast agents

被引：135

作者：

Corr, Serena A. ^{[1
]}

Byrne, Stephen J. ^{[1
]}

Tekoriute, Renata ^{[1
]}

Meledandri, Carla J. ^{[2
]}

Brougham, Dermot F. ^{[2
]}

Lynch, Marina ^{[3
]}

Kerskens, Christian ^{[3
]}

O'Dwyer, Laurence ^{[3
]}

Gun'ko, Yurii K. ^{[1
]}

机构：

[1] Univ Dublin, Trinity Coll, Sch Chem, Dublin 2, Ireland

[2] Dublin City Univ, Sch Chem Sci, Natl Inst Cellular Biotechnol, Dublin 9, Ireland

[3] Univ Dublin, Inst Neurosci, Dublin 2, Ireland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 13期

关键词：

D O I：

10.1021/ja710172z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using a one-step procedure we have prepared magnetic fluids comprising of polyelectrolyte stabilized magnetite nanoparticles. These nanocomposites are comprised of linear, chain-like assemblies of magnetic nanoparticles, which can be aligned in parallel arrays by an external magnetic field. We have shown the potential use of these materials as contrast agents by measuring their MR response in live rats. The new magnetic fluids have demonstrated good biocompatibility and potential for in vivo MRI diagnostics.

引用

页码：4214 / +

页数：3

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