K11-linked ubiquitin chains as novel regulators of cell division

被引：141

作者：

Wickliffe, Katherine E. ^{[1
]}

Williamson, Adam ^{[1
]}

Meyer, Hermann-Josef ^{[1
]}

Kelly, Aileen ^{[1
]}

Rape, Michael ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

TRENDS IN CELL BIOLOGY | 2011年 / 21卷 / 11期

基金：

美国国家卫生研究院;

关键词：

CONJUGATING ENZYME; SPINDLE CHECKPOINT; MULTIUBIQUITIN CHAIN; FUNCTIONAL-ANALYSIS; PROTEIN; CYCLIN; E2; REVEALS; COMPLEX; UBCH10;

D O I：

10.1016/j.tcb.2011.08.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Modification of proteins with ubiquitin chains is an essential regulatory event in cell cycle control. Differences in the connectivity of ubiquitin chains are believed to result in distinct functional consequences for the modified proteins. Among eight possible homogenous chain types, canonical Lys48-linked ubiquitin chains have long been recognized to drive the proteasomal degradation of cell cycle regulators, and Lys48 is the only essential lysine residue of ubiquitin in yeast. It thus came as a surprise that in higher eukaryotes atypical K11-linked ubiquitin chains regulate the substrates of the anaphase-promoting complex and control progression through mitosis. We discuss recent findings that shed light on the assembly and function of K11-linked chains during cell division.

引用

页码：656 / 663

页数：8

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