Nipah virus: Vaccination and passive protection studies in a hamster model

被引:159
作者
Guillaume, V
Contamin, H
Loth, P
Georges-Courbot, MC
Lefeuvre, A
Marianneau, P
Chua, KB
Lam, SK
Buckland, R
Deubel, V
Wild, TF
机构
[1] CERVI, INSERM, IFR 128, U 404, F-69365 Lyon 07, France
[2] CERVI, UBIVE, F-69365 Lyon 07, France
[3] CERVI, Inst Pasteur, F-69365 Lyon 07, France
[4] Univ Malaya, Kuala Lumpur, Malaysia
关键词
D O I
10.1128/JVI.78.2.834-840.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Nipah virus, a member of the paramyxovirus family, was first isolated and identified in 1999 when the virus crossed the species barrier from fruit bats to pigs and then infected humans, inducing an encephalitis with up to 40% mortality. At present there is no prophylaxis for Nipah virus. We investigated the possibility of vaccination and passive transfer of antibodies as interventions against this disease. We show that both of the Nipah virus glycoproteins (G and F) when expressed as vaccinia virus recombinants induced an immune response in hamsters which protected against a lethal challenge by Nipah virus. Similarly, passive transfer of antibody induced by either of the glycoproteins protected the animals. In both the active and passive immunization studies, however, the challenge virus was capable of hyperimmunizing the vaccinated animals, suggesting that although the virus replicates under these conditions, the immune system can eventually control the infection.
引用
收藏
页码:834 / 840
页数:7
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