Calcineurin signaling in Saccharomyces cereviside:: how yeast go crazy in response to stress

被引：281

作者：

Cyert, MS ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94306 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 311卷 / 04期

关键词：

D O I：

10.1016/S0006-291X(03)01552-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In the yeast Saccharomyces cerevisiae, Ca2+ signaling mediated by the Ca2+/calmodulin dependent phosphatase, calcineurin, is required for survival during environmental stress. One role of the phosphatase under these conditions is to activate gene expression through its regulation of the Crz1p ("crazy") transcription factor. Calcineurin dephosphorylates Crz1p and causes its rapid translocation from the cytosol to the nucleus. Crz1p then activates the transcription of genes whose products promote cell survival. Recent studies concerning the regulation of Crz1p by calcineurin are discussed in this review and the mechanisms by which calcineurin controls gene expression in yeast and mammalian cells are compared. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1143 / 1150

页数：8

共 63 条

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