Sensing damage by the NLRP3 inflammasome

被引：225

作者：

Leemans, Jaklien C. ^{[2
]}

Cassel, Suzanne L. ^{[1
,4
,5
]}

Sutterwala, Fayyaz S. ^{[1
,3
,5
]}

机构：

[1] Univ Iowa, Coralville, IA 52241 USA

[2] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Iowa, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USA

[4] Univ Iowa, Dept Internal Med, Div Immunol, Iowa City, IA 52242 USA

[5] Univ Iowa, Dept Internal Med, Inflammat Program, Iowa City, IA 52242 USA

来源：

IMMUNOLOGICAL REVIEWS | 2011年 / 243卷

关键词：

NLRP3; inflammasome; caspase-1; sterile inflammation; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ISCHEMIA-REPERFUSION INJURY; MUCKLE-WELLS-SYNDROME; COLD AUTOINFLAMMATORY SYNDROME; ACUTE MYOCARDIAL-INFARCTION; PROGRESSIVE RENAL INJURY; INNATE IMMUNE-RESPONSE; NALP3; INFLAMMASOME; ISCHEMIA/REPERFUSION INJURY; ACTIVATES CASPASE-1;

D O I：

10.1111/j.1600-065X.2011.01043.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The NLRP3 inflammasome is activated in response to a variety of signals that are indicative of damage to the host including tissue damage, metabolic stress, and infection. Upon activation, the NLRP3 inflammasome serves as a platform for activation of the cysteine protease caspase-1, which leads to the processing and secretion of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18. Dysregulated NLRP3 inflammasome activation is associated with both heritable and acquired inflammatory diseases. Here, we review new insights into the mechanism of NLRP3 inflammasome activation and its role in disease pathogenesis.

引用

页码：152 / 162

页数：11

共 98 条

[61] REACTIVE MICROGLIA IN PATIENTS WITH SENILE DEMENTIA OF ALZHEIMER TYPE ARE POSITIVE FOR THE HISTOCOMPATIBILITY GLYCOPROTEIN HLA-DR
MCGEER, PL
ITAGAKI, S
TAGO, H
MCGEER, EG
[J]. NEUROSCIENCE LETTERS, 1987, 79 (1-2) : 195 - 200
[62] Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity
McKee, Amy S.
Munks, Michael W.
MacLeod, Megan K. L.
Fleenor, Courtney J.
Van Rooijen, Nico
Kappler, John W.
Marrack, Philippa
[J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (07) : 4403 - 4414
[63] Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
Meissner, Felix
Molawi, Kaaweh
Zychlinsky, Arturo
[J]. NATURE IMMUNOLOGY, 2008, 9 (08) : 866 - 872
[64] Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome
Menu, P.
Pellegrin, M.
Aubert, J-F
Bouzourene, K.
Tardivel, A.
Mazzolai, L.
Tschopp, J.
[J]. CELL DEATH & DISEASE, 2011, 2 : e137 - e137
[65] Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer's disease
Meyer-Luehmann, Melanie
Spires-Jones, Tara L.
Prada, Claudia
Garcia-Alloza, Monica
de Calignon, Alix
Rozkalne, Anete
Koenigsknecht-Talboo, Jessica
Holtzman, David M.
Bacskai, Brian J.
Hyman, Bradley T.
[J]. NATURE, 2008, 451 (7179) : 720 - U5
[66] Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
Miao, Edward A.
Alpuche-Aranda, Celia M.
Dors, Monica
Clark, April E.
Bader, Martin W.
Miller, Samuel I.
Aderem, Alan
[J]. NATURE IMMUNOLOGY, 2006, 7 (06) : 569 - 575
[67] Targeting IL-1β in disease; the expanding role of NLRP3 inflammasome
Mitroulis, Ioannis
Skendros, Panagiotis
Ritis, Konstantinos
[J]. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2010, 21 (03) : 157 - 163
[68] Adipose and Liver Expression of Interleukin (IL)-1 Family Members in Morbid Obesity and Effects of Weight Loss
Moschen, Alexander R.
Molnar, Clemens
Enrich, Barbara
Geiger, Sabine
Ebenbichler, Christoph F.
Tilg, Herbert
[J]. MOLECULAR MEDICINE, 2011, 17 (7-8) : 840 - 845
[69] Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nakahira, Kiichi
Haspel, Jeffrey Adam
Rathinam, Vijay A. K.
Lee, Seon-Jin
Dolinay, Tamas
Lam, Hilaire C.
Englert, Joshua A.
Rabinovitch, Marlene
Cernadas, Manuela
Kim, Hong Pyo
Fitzgerald, Katherine A.
Ryter, Stefan W.
Choi, Augustine M. K.
[J]. NATURE IMMUNOLOGY, 2011, 12 (03) : 222 - U57
[70] Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
Netea, MG
Joosten, LAB
Lewis, E
Jensen, DR
Voshol, PJ
Kullberg, BJ
Tack, CJ
van Krieken, H
Kim, SH
Stalenhoef, AF
Van de Loo, FA
Verschueren, I
Pulawa, L
Akira, S
Eckel, RH
Dinarello, CA
Van den Berg, W
Van der Meer, JWM
[J]. NATURE MEDICINE, 2006, 12 (06) : 650 - 656

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