Treatment of acute graft-versus-host disease with PUVA (psoralen and ultraviolet irradiation): results of a pilot study

被引:31
作者
Wiesmann, A
Weller, A
Lischka, G
Klingebiel, T
Kanz, L
Einsele, H
机构
[1] Univ Tubingen, Dept Hematol & Oncol, D-72076 Tubingen, Germany
[2] Univ Tubingen, Dept Dermatol, D-72076 Tubingen, Germany
[3] Univ Tubingen, Dept Pediat, D-72076 Tubingen, Germany
关键词
allogeneic stem cell transplantation; acute GVHD; PUVA;
D O I
10.1038/sj.bmt.1701537
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Acute graft-versus-host disease (aGVHD) is a frequent and major complication after allogeneic stem cell transplantation, For many years psoralen and ultraviolet (UV)-A light have been used in the treatment of chronic cutaneous graft-versus-host disease, but few patients have received PUVA therapy for aGVHD, We assessed 20 patients who received PUVA therapy for acute cutaneous GVHD (grade 2-4), Seven patients showed additional organ manifestations (liver, gut). To better quantify the cutaneous lesions, a new scoring system was introduced: intensity of erythema (0-3) x %body surface + size of bullae (4-5) x %body surface affected. All patients received prednisolone and PUVA for treatment of aGVHD. Fifteen patients (75%), 12 with manifestations restricted to the skin, responded by score classification (average time to a 50% score reduction: 39 days) and reduction of the dosage of prednisolone (average time to a 50% prednisolone reduction: 35 days). PUVA treatment was well tolerated and might play a role in the therapy of acute cutaneous GVHD.
引用
收藏
页码:151 / 155
页数:5
相关论文
共 32 条
[21]   THE EFFECT OF 8-METHOXYPSORALEN AND LONG-WAVE ULTRAVIOLET-LIGHT ON LANGERHANS CELL [J].
OKAMOTO, H ;
HORIO, T .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1981, 77 (04) :345-346
[22]   ALTERATION OF LYMPHOCYTE FUNCTIONS BY 8-METHOXYPSORALEN AND LONG-WAVE ULTRAVIOLET-RADIATION .2. THE EFFECT OF INVIVO PUVA ON IL-2 PRODUCTION [J].
OKAMOTO, H ;
HORIO, T ;
MAEDA, M .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1987, 89 (01) :24-26
[23]  
OWSIANOWSKI M, 1994, BONE MARROW TRANSPL, V14, P845
[24]   INHIBITION OF ANTISKIN ALLOGRAFT IMMUNITY BY INFUSIONS WITH SYNGENEIC PHOTOINACTIVATED EFFECTOR LYMPHOCYTES [J].
PEREZ, M ;
EDELSON, R ;
LAROCHE, L ;
BERGER, C .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1989, 92 (05) :669-676
[26]  
REINAUER S, 1993, HAUTARZT, V44, P708
[27]  
RIVAS JM, 1992, J IMMUNOL, V149, P3865
[28]  
Rossetti F, 1996, BONE MARROW TRANSPL, V18, P175
[29]  
SIMON JC, 1991, J IMMUNOL, V146, P485
[30]  
TORRAS H, 1993, EUR J DERMATOL, V3, P447