Delayed post-ischemic albumin treatment neither improves nor worsens the outcome of transient focal cerebral ischemia in rats

被引：11

作者：

Belayev, L ^{[1
]}

Khoutorova, L ^{[1
]}

Belayev, A ^{[1
]}

Zhang, YB ^{[1
]}

Zhao, WZ ^{[1
]}

Busto, R ^{[1
]}

Ginsberg, MD ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Neurol D4 5, Cerebral Vasc Dis Res Ctr, Miami, FL 33101 USA

来源：

BRAIN RESEARCH | 2004年 / 998卷 / 02期

关键词：

neuroprotection; stroke; edema; hemodilution;

D O I：

10.1016/j.brainres.2003.11.015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human albumin therapy within the first 4 h is highly neuroprotective in focal ischemia, but it is unknown whether delayed albumin therapy is deleterious. Rats received 2 h middle cerebral artery suture-occlusion. Human albumin (25%, 2.5 mg/kg; n=12) or vehicle (0.9% saline, 5 ml/kg; n=9) were administered at 19 h. Neurological status was evaluated daily, and histopathology and brain swelling were quantified at 3 days. Delayed albumin treatment, while ineffective, failed to show adverse effects. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：243 / 246

页数：4

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