Rhythm control versus rate control for atrial fibrillation and heart failure

被引：1141

作者：

Roy, Denis ^{[1
,2
]}

Talajic, Mario ^{[1
,2
]}

Nattel, Stanley ^{[1
,2
]}

Wyse, D. George ^{[3
]}

Dorian, Paul ^{[4
]}

Lee, Kerry L. ^{[5
]}

Bourassa, Martial G. ^{[1
,2
]}

Arnold, J. Malcolm O. ^{[6
]}

Buxton, Alfred E. ^{[7
]}

Camm, A. John ^{[8
]}

Connolly, Stuart J. ^{[9
]}

Dubuc, Marc ^{[1
,2
]}

Ducharme, Anique ^{[1
,2
]}

Guerra, Peter G. ^{[1
,2
]}

Hohnloser, Stefan H. ^{[10
]}

Lambert, Jean ^{[1
,2
]}

Le Heuzey, Jean-Yves ^{[11
]}

O'Hara, Gilles ^{[12
]}

Pedersen, Ole Dyg ^{[13
]}

Rouleau, Jean-Lucien ^{[1
,2
]}

Singh, Bramah N. ^{[14
]}

Stevenson, Lynne Warner ^{[15
]}

Stevenson, William G. ^{[15
]}

Thibault, Bernard ^{[1
,2
]}

Waldo, Albert L. ^{[16
]}

机构：

[1] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada

[2] Univ Montreal, Montreal, PQ, Canada

[3] Libin Cardiovasc Inst, Calgary, AB, Canada

[4] St Michaels Hosp, Toronto, ON M5B 1W8, Canada

[5] Duke Univ, Med Ctr, Durham, NC USA

[6] London Hlth Sci Ctr, London, ON, Canada

[7] Rhode Isl Hosp, Lifespan Acad Ctr, Providence, RI USA

[8] Univ London St Georges Hosp, Med Ctr, London, England

[9] Populat Hlth Res Inst, Hamilton, ON, Canada

[10] Goethe Univ Frankfurt, Frankfurt, Germany

[11] Hop Europeen Georges Pompidou, Paris, France

[12] Inst Cardiol Quebec, Quebec City, PQ, Canada

[13] Bispebjerg Hosp, Copenhagen, Denmark

[14] W Los Angeles Vet Affairs Med Ctr, Los Angeles, CA 90073 USA

[15] Brigham & Womens Hosp, Boston, MA 02115 USA

[16] Case Western Reserve Univ Hosp, Med Ctr, Cleveland, OH 44106 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 25期

关键词：

D O I：

10.1056/NEJMoa0708789

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background It is common practice to restore and maintain sinus rhythm in patients with atrial fibrillation and heart failure. This approach is based in part on data indicating that atrial fibrillation is a predictor of death in patients with heart failure and suggesting that the suppression of atrial fibrillation may favorably affect the outcome. However, the benefits and risks of this approach have not been adequately studied. Methods We conducted a multicenter, randomized trial comparing the maintenance of sinus rhythm (rhythm control) with control of the ventricular rate (rate control) in patients with a left ventricular ejection fraction of 35% or less, symptoms of congestive heart failure, and a history of atrial fibrillation. The primary outcome was the time to death from cardiovascular causes. Results A total of 1376 patients were enrolled (682 in the rhythm-control group and 694 in the rate-control group) and were followed for a mean of 37 months. Of these patients, 182 (27%) in the rhythm-control group died from cardiovascular causes, as compared with 175 (25%) in the rate-control group (hazard ratio in the rhythm-control group, 1.06; 95% confidence interval, 0.86 to 1.30; P=0.59 by the log-rank test). Secondary outcomes were similar in the two groups, including death from any cause (32% in the rhythm-control group and 33% in the rate-control group), stroke (3% and 4%, respectively), worsening heart failure (28% and 31%), and the composite of death from cardiovascular causes, stroke, or worsening heart failure (43% and 46%). There were also no significant differences favoring either strategy in any predefined subgroup. Conclusions In patients with atrial fibrillation and congestive heart failure, a routine strategy of rhythm control does not reduce the rate of death from cardiovascular causes, as compared with a rate-control strategy.

引用

页码：2667 / 2677

页数：11

共 43 条

[41] A comparison of rate control and rhythm control in patients with atrial fibrillation [J].