Critical role of the interleukin-23//T-helper 17 cell axis in the pathogenesis of psoriasis

被引：75

作者：

Nakajima, Kimiko ^{[1
]}

机构：

[1] Kochi Univ, Kochi Med Sch, Dept Dermatol, Nanko Ku, Kochi 7838505, Japan

来源：

JOURNAL OF DERMATOLOGY | 2012年 / 39卷 / 03期

关键词：

biologics; interleukin-23; T-helper 17 cell axis; mouse model; psoriasis; Stat3; T-CELLS; AUTOIMMUNE INFLAMMATION; EPIDERMAL HYPERPLASIA; ANTIMICROBIAL PEPTIDE; HUMAN KERATINOCYTES; SKIN INFLAMMATION; INTERLEUKIN; 22; EXPRESSION; CYTOKINES; IL-17;

D O I：

10.1111/j.1346-8138.2011.01458.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis is an inflammatory disease with dynamic interactions between the immune system and the skin. Recent studies have demonstrated that the interleukin (IL)-23//T-helper (Th)17 cell axis plays an important role in the pathogenesis of psoriasis. Here, the biology and function of Th17 cells as well as the crucial role of IL-23 in the context of the Th17 cell-dependent chronic inflammation in psoriatic skins are reviewed. Recent study about the role of the IL-23//Th17 axis in the pathogenesis of psoriasis-like lesions in K5.Stat3C transgenic mice is also discussed. This model mouse for psoriasis not only verifies the therapeutic efficacies of biologics that specifically target the IL-23//Th17 axis, but also clarifies the pathogenesis of psoriasis.

引用

页码：219 / 224

页数：6

共 42 条

[1] Serum levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17 and IL-18 in patients with active psoriasis and correlation with disease severity [J].

Arican, O ;

Aral, M ;

Sasmaz, S ;

Ciragil, P .

MEDIATORS OF INFLAMMATION, 2005, (05) :273-279

[2] A role for T cell-derived interleukin 22 in psoriatic skin inflammation [J].

Boniface, K. ;

Guignouard, E. ;

Pedretti, N. ;

Garcia, M. ;

Delwail, A. ;

Bernard, F. -X. ;

Nau, F. ;

Guillet, G. ;

Dagregorio, G. ;

Yssel, H. ;

Lecron, J. -C. ;

Morel, F. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 150 (03) :407-415

[3] IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes [J].

Boniface, K ;

Bernard, FX ;

Garcia, M ;

Gurney, AL ;

Lecron, JC ;

Morel, F .

JOURNAL OF IMMUNOLOGY, 2005, 174 (06) :3695-3702

[4] Natural killer and natural killer-T cells in psoriasis [J].

Cameron, AL ;

Kirby, B ;

Fei, W ;

Griffiths, CEM .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 2002, 294 (08) :363-369

[5] IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis [J].

Chan, Jason R. ;

Blumenschein, Wendy ;

Murphy, Erin ;

Diveu, Caroline ;

Wiekowski, Maria ;

Abbondanzo, Susan ;

Lucian, Linda ;

Geissler, Richard ;

Brodie, Scott ;

Kimball, Alexa B. ;

Gorman, Daniel M. ;

Smith, Kathleen ;

Malefyt, Rene de Waal ;

Kastelein, Robert A. ;

McClanahan, Terrill K. ;

Bowman, Edward P. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (12) :2577-2587

[6] Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain [J].

Cua, DJ ;

Sherlock, J ;

Chen, Y ;

Murphy, CA ;

Joyce, B ;

Seymour, B ;

Lucian, L ;

To, W ;

Kwan, S ;

Churakova, T ;

Zurawski, S ;

Wiekowski, M ;

Lira, SA ;

Gorman, D ;

Kastelein, RA ;

Sedgwick, JD .

NATURE, 2003, 421 (6924) :744-748

[7] The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis [J].

Di Cesare, Antonella ;

Di Meglio, Paola ;

Nestle, Frank O. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (06) :1339-1350

[8]

Di Megllo P, 2011, PLOS ONE, V22

[9] Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells [J].

Duhen, Thomas ;

Geiger, Rebekka ;

Jarrossay, David ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

NATURE IMMUNOLOGY, 2009, 10 (08) :857-U72

[10] Molecular Dissection of Psoriasis: Integrating Genetics and Biology [J].

Elder, James T. ;

Bruce, Allen T. ;

Gudjonsson, Johann E. ;

Johnston, Andrew ;

Stuart, Philip E. ;

Tejasvi, Trilokraj ;

Voorhees, John J. ;

Abecasis, Goncalo R. ;

Nair, Rajan P. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (05) :1213-1226

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