The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

被引：871

作者：

Di Cesare, Antonella ^{[1
,2
,3
]}

Di Meglio, Paola ^{[1
,2
]}

Nestle, Frank O. ^{[1
,2
]}

机构：

[1] Guys Hosp, St Johns Inst Dermatol, Kings Coll London, Sch Med, London SE1 9RT, England

[2] NIHR Biomed Res Ctr, London, England

[3] Univ Aquila, Dept Dermatol, I-67100 Laquila, Italy

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2009年 / 129卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; GROWTH-FACTOR-BETA; T-HELPER-CELLS; ROR-GAMMA-T; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; INFLAMMATORY-BOWEL-DISEASE; ACTIVE CROHNS-DISEASE; MULTIPLE-SCLEROSIS LESIONS; ARYL-HYDROCARBON RECEPTOR; NECROSIS-FACTOR-ALPHA;

D O I：

10.1038/jid.2009.59

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis. Journal of Investigative Dermatology (2009) 129, 1339-1350; doi:10.1038/jid.2009.59; published online 26 March 2009

引用

页码：1339 / 1350

页数：12

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