Evolution of cell recognition by viruses

被引:201
作者
Baranowski, E [1 ]
Ruiz-Jarabo, CM [1 ]
Domingo, E [1 ]
机构
[1] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain
关键词
D O I
10.1126/science.1058613
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Evolution of receptor specificity by viruses has several implications for viral pathogenesis, host range, virus-mediated gene targeting, and viral adaptation after organ transplantation and xenotransplantation, as well as for the emergence of viral diseases. Recent evidence suggests that minimal changes in viral genomes may trigger a shift in receptor usage for virus entry, even into the same cell type. A capacity to exploit alternative entry pathways may reflect the-ancient evolutionary origins of viruses and a possible role as agents of horizontal gene transfers among cells.
引用
收藏
页码:1102 / 1105
页数:4
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