3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier

被引：19

作者：

Baik, Hye Jung ^{[1
]}

Oh, Nam Muk ^{[1
]}

Oh, Young Taik ^{[2
]}

Yoo, Na Young ^{[1
]}

Park, So Young ^{[1
]}

Oh, Kyung Taek ^{[3
]}

Youn, Yu Seok ^{[4
]}

Lee, Eun Seong ^{[1
]}

机构：

[1] Catholic Univ Korea, Div Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea

[2] Yonsei Univ, Coll Med, Dept Diagnost Radiol, Seoul 120752, South Korea

[3] Chung Ang Univ, Coll Pharm, Seoul 155756, South Korea

[4] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2011年 / 84卷 / 02期

关键词：

Polysaccharidic nanogels; Glycol chitosan; Bovine serum albumin; Ph-sensitivity; DELIVERY; NANOPARTICLES; NANOGELS; CELLS;

D O I：

10.1016/j.colsurfb.2011.01.017

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Polysaccharidic nanogels were fabricated with bovine serum albumin (BSA) and a glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups. These nanogels were investigated to evaulate their cellular uptake in HeLa cells and in vivo fate in nude mice tumor model. Unlike free BSA, GCS-g-DEAP/BSA nanogels improved cellular uptake of BSA. Furthermore, this system led to an enhanced blood circulation and a high accumulation of BSA in the tumor site. Our collective results strongly support that GCS-g-DEAP/BSA nanogel is a potential carrier system for high molecular weight proteins. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：585 / 590

页数：6

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