Innovation -: Rescuing drug discovery:: in vivo systems pathology and systems pharmacology

被引：146

作者：

van der Greef, J

McBurney, RN

机构：

[1] TNO Syst Biol, Netherlands Org Appl Sci Res, NL-3700 AJ Zeist, Netherlands

[2] Leiden Amsterdam Ctr Drug Res, Ctr Med Syst Biol, NL-2300 RA Leiden, Netherlands

[3] BG Med Inc, Waltham, MA 02451 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2005年 / 4卷 / 12期

关键词：

D O I：

10.1038/nrd1904

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The pharmaceutical industry is currently beleaguered by close scrutiny from the financial community, regulators and the general public. Productivity, in terms of new drug approvals, has generally been falling for almost a decade and the safety of a number of highly successful drugs has recently been brought into question. Here, we discuss whether taking an in vivo systems approach to drug discovery and development could be the paradigm shift that rescues the industry.

引用

页码：961 / 967

页数：7

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