Enantioselective total synthesis of (-)-flustramines A, B and (-)-flustramides A, B via domino olefination/isomerization/Claisen rearrangement sequence

被引：56

作者：

Kawasaki, T ^{[1
]}

Shinada, M ^{[1
]}

Kamimura, D ^{[1
]}

Ohzono, M ^{[1
]}

Ogawa, A ^{[1
]}

机构：

[1] Mieji Pharmaceut Univ, Tokyo 2048588, Japan

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 04期

关键词：

D O I：

10.1039/b512485a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The concise total synthesis of marine alkaloids, (-)-flustramines A and B, and (-)-flustramides A and B has been achieved through the domino olefination/isomerization/Claisen rearrangement (OIC) for highly enantioselective construction of the asymmetric quaternary carbon center and the chemoselective reduction-cyclization (RC) for pyrrolidine formation as key steps.

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收藏

页码：420 / 422

页数：3

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