Retroviruses as tools to study the immune system

被引：29

作者：

Lois, C

Refaeli, Y

Qin, XF

Van Parijs, L

机构：

[1] MIT, Dept Biol, Ctr Canc Res, Cambridge, MA 02139 USA

[2] Univ Calif San Francisco, George Williams Hooper Fdn, San Francisco, CA 94143 USA

[3] CALTECH, Dept Biol, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00247-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Retrovirus-based vectors provide an efficient means to introduce and express genes in cells of the immune system and have become a popular tool to study immune function. They are easy to manipulate and provide stable, long-term gene expression because they integrate into the genome. Current retroviral vectors do have limitations that affect their usefulness in certain applications. However. recent advances suggest a number of ways in which these vectors might be improved to extend their utility in immunological research.

引用

页码：496 / 504

页数：9

共 68 条

[1] A PUTATIVE MURINE ECOTROPIC RETROVIRUS RECEPTOR GENE ENCODES A MULTIPLE MEMBRANE-SPANNING PROTEIN AND CONFERS SUSCEPTIBILITY TO VIRUS-INFECTION
ALBRITTON, LM
TSENG, L
SCADDEN, D
CUNNINGHAM, JM
[J]. CELL, 1989, 57 (04) : 659 - 666
[2] THE USE OF ADENOVIRAL VECTORS FOR GENE-THERAPY AND GENE-TRANSFER IN-VIVO
BRAMSON, JL
GRAHAM, FL
GAULDIE, J
[J]. CURRENT OPINION IN BIOTECHNOLOGY, 1995, 6 (05) : 590 - 595
[3] Buchschacher GL, 2000, BLOOD, V95, P2499
[4] VESICULAR STOMATITIS-VIRUS G GLYCOPROTEIN PSEUDOTYPED RETROVIRAL VECTORS - CONCENTRATION TO VERY HIGH-TITER AND EFFICIENT GENE-TRANSFER INTO MAMMALIAN AND NONMAMMALIAN CELLS
BURNS, JC
FRIEDMANN, T
DRIEVER, W
BURRASCANO, M
YEE, JK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) : 8033 - 8037
[5] Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice
Chen, WY
Wu, XY
Levasseur, DN
Liu, HM
Lai, LL
Kappes, JC
Townes, TM
[J]. STEM CELLS, 2000, 18 (05) : 352 - 359
[6] Retroviral expression in embryonic stem cells and hematopoietic stem cells
Cherry, SR
Biniszkiewicz, D
van Parijs, L
Baltimore, D
Jaenisch, R
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (20) : 7419 - 7426
[7] Coffin JM, 1997, RETROVIRUSES
[8] Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease
Costa, GL
Benson, JM
Seroogy, CM
Achacoso, P
Fathman, CG
Nolan, GP
[J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (07) : 3581 - 3590
[9] The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
Crompton, T
Gilmour, KC
Owen, MJ
[J]. CELL, 1996, 86 (02) : 243 - 251
[10] Efficient transduction of nondividing cells by optimized feline immunodeficiency virus vectors
Curran, MA
Kaiser, SM
Achacoso, PL
Nolan, GP
[J]. MOLECULAR THERAPY, 2000, 1 (01) : 31 - 38

← 1 2 3 4 5 6 7 →