Eicosapentaenoic acid: biosynthetic routes and the potential for synthesis in transgenic plants

被引：130

作者：

Sayanova, OV ^{[1
]}

Napier, JA ^{[1
]}

机构：

[1] Rothamsted Res, Harpenden AL5 2JQ, Herts, England

来源：

PHYTOCHEMISTRY | 2004年 / 65卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

polyunsaturated fatty acids; eicosapentaenoic acid; metabolic engineering; metabolic syndrome; plant biotechnology;

D O I：

10.1016/j.phytochem.2003.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long chain polyunsaturated fatty acids are now known to play important roles in human health. In particular, eicosapentaenoic acid (20:5Delta(5,8,11,14,17); n-3: EPA) is implicated as a protective agent in a range of pathologies such as cardiovascular disease and Metabolic Syndrome (Syndrome X). Eicosapentaenoic acid is currently sourced from fish oils, the presence of this fatty acid being due to the dietary piscine consumption of EPA-synthesising micro-algae. The biosynthetic pathway of EPA has been elucidated, and contains several alternative metabolic routes. Progress in using "reverse engineering" to transgenically mobilize the trait(s) for EPA are considered. In particular, the prospect of producing this important polyunsaturated fatty acid in transgenic oilseeds is highlighted, as is the urgent need for a sustainable replacement for diminishing fish stocks. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：147 / 158

页数：12

共 92 条

[21] Prostaglandins and leukotrienes: Advances in eicosanoid biology [J].