Gold(I)-catalyzed intramolecular acetylenic Schmidt reaction

被引：482

作者：

Gorin, DJ ^{[1
]}

Davis, NR ^{[1
]}

Toste, FD ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 32期

关键词：

D O I：

10.1021/ja053804t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Substituted pyrroles were prepared by a gold(I)-catalyzed acetylenic Schmidt reaction of homopropargyl azides. The reaction allows for regiospecific substitution at each position of the pyrrole ring under mild conditions. A mechanism in which azides serve as nucleophiles toward gold(I)-activated alkynes with subsequent gold(I)-aided expulsion of dinitrogen is proposed. Copyright © 2005 American Chemical Society.

引用

页码：11260 / 11261

页数：2

共 42 条

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