Epigenetic regulation of stem cell fate

被引：106

作者：

Lunyak, Victoria V. ^{[1
]}

Rosenfeld, Michael G. ^{[2
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

[2] Univ Calif San Diego, Sch Med, Dept Mol Med, Howard Hughes Med Inst, San Diego, CA 92093 USA

来源：

HUMAN MOLECULAR GENETICS | 2008年 / 17卷

关键词：

D O I：

10.1093/hmg/ddn149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stem cell-based regenerative medicine holds great promise for repair of diseased tissue. Modern directions in the field of epigenetic research aimed to decipher the epigenetic signals that give stem cells their unique ability to self-renew and differentiate into different cell types. However, this research is only the tip of the iceberg when it comes to writing an 'epigenetic instruction manual' for the ramification of molecular details of cell commitment and differentiation. In this review, we discuss the impact of the epigenetic research on our understanding of stem cell biology.

引用

收藏

页码：R28 / R36

页数：9

相关论文

共 105 条

[1] UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development [J].

Agger, Karl ;

Cloos, Paul A. C. ;

Christensen, Jesper ;

Pasini, Diego ;

Rose, Simon ;

Rappsilber, Juri ;

Issaeva, Irina ;

Canaani, Eli ;

Salcini, Anna Elisabetta ;

Helin, Kristian .

NATURE, 2007, 449 (7163) :731-U10

[2] Differential nuclear remodeling of mammalian somatic cells by Xenopus laevis oocyte and egg cytoplasm [J].

Alberio, R ;

Johnson, AD ;

Stick, R ;

Campbell, KHS .

EXPERIMENTAL CELL RESEARCH, 2005, 307 (01) :131-141

[3] Epigenetic modification is central to genome reprogramming in somatic cell nuclear transfer [J].

Armstrong, Lyle ;

Lako, Majlinda ;

Dean, Wendy ;

Stojkovic, Miodrag .

STEM CELLS, 2006, 24 (04) :805-814

[4] The role of PI3K/AKT, MAPK/ERK and NFκβ signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis [J].

Armstrong, Lyle ;

Hughes, Owen ;

Yung, Sun ;

Hyslop, Louise ;

Stewart, Rebecca ;

Wappler, Ilka ;

Peters, Heiko ;

Walter, Theresia ;

Stojkovic, Petra ;

Evans, Jerome ;

Stojkovic, Miodrag ;

Lako, Majlinda .

HUMAN MOLECULAR GENETICS, 2006, 15 (11) :1894-1913

[5] Chromatin signatures of pluripotent cell lines [J].

Azuara, V ;

Perry, P ;

Sauer, S ;

Spivakov, M ;

Jorgensen, HF ;

John, RM ;

Gouti, M ;

Casanova, M ;

Warnes, G ;

Merkenschlager, M ;

Fisher, AG .

NATURE CELL BIOLOGY, 2006, 8 (05) :532-U189

[6] The many faces of REST oversee epigenetic programming of neuronal genes [J].

Ballas, N ;

Mandel, G .

CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (05) :500-506

[7] A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].

Bernstein, BE ;

Mikkelsen, TS ;

Xie, XH ;

Kamal, M ;

Huebert, DJ ;

Cuff, J ;

Fry, B ;

Meissner, A ;

Wernig, M ;

Plath, K ;

Jaenisch, R ;

Wagschal, A ;

Feil, R ;

Schreiber, SL ;

Lander, ES .

CELL, 2006, 125 (02) :315-326

[8] Covalent modifications of histones during development and disease pathogenesis [J].

Bhaumik, Sukesh R. ;

Smith, Edwin ;

Shilatifard, Ali .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (11) :1008-1016

[9] Human embryonic stem cells have a unique epigenetic signature [J].

Bibikova, Marina ;

Chudin, Eugene ;

Wu, Bonnie ;

Zhou, Lixin ;

Garcia, Eliza Wickham ;

Liu, Ying ;

Shin, Soojung ;

Plaia, Todd W. ;

Auerbach, Jonathan M. ;

Arking, Dan E. ;

Gonzalez, Rodolfo ;

Crook, Jeremy ;

Davidson, Bruce ;

Schulz, Thomas C. ;

Robins, Allan ;

Khanna, Aparna ;

Sartipy, Peter ;

Hyllner, Johan ;

Vanguri, Padmavathy ;

Savant-Bhonsale, Smita ;

Smith, Alan K. ;

Chakravarti, Aravinda ;

Maitra, Anirban ;

Rao, Mahendra ;

Barker, David L. ;

Loring, Jeanne F. ;

Fan, Jian-Bing .

GENOME RESEARCH, 2006, 16 (09) :1075-1083

[10] Comparative genomics at the vertebrate extremes [J].

Boffelli, D ;

Nobrega, MA ;

Rubin, EM .

NATURE REVIEWS GENETICS, 2004, 5 (06) :456-465

← 1 2 3 4 5 6 7 8 9 10 →