Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task

被引:736
作者
Jones, MW [1 ]
Wilson, MA [1 ]
机构
[1] MIT, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, RIKEN,MIT Neurosci Res Ctr, Cambridge, MA 02139 USA
基金
英国惠康基金;
关键词
D O I
10.1371/journal.pbio.0030402
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Decision-making requires the coordinated activity of diverse brain structures. For example, in maze-based tasks, the prefrontal cortex must integrate spatial information encoded in the hippocampus with mnemonic information concerning route and task rules in order to direct behavior appropriately. Using simultaneous tetrode recordings from CA1 of the rat hippocampus and medial prefrontal cortex, we show that correlated firing in the two structures is selectively enhanced during behavior that recruits spatial working memory, allowing the integration of hippocampal spatial information into a broader, decision-making network. The increased correlations are paralleled by enhanced coupling of the two structures in the 4- to 12- Hz theta-frequency range. Thus the coordination of theta rhythms may constitute a general mechanism through which the relative timing of disparate neural activities can be controlled, allowing specialized brain structures to both encode information independently and to interact selectively according to current behavioral demands.
引用
收藏
页码:2187 / 2199
页数:13
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