共 21 条
Novel anticancer compounds induce apoptosis in melanoma cells
被引:71
作者:

Bhat, Uppoor G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Med, Chicago, IL 60612 USA Univ Illinois, Dept Med, Chicago, IL 60612 USA

Zipfel, Patricia A.
论文数: 0 引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
Durham Vet Affairs Med Ctr, Dept Surg, Durham, NC USA Univ Illinois, Dept Med, Chicago, IL 60612 USA

Tyler, Douglas S.
论文数: 0 引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
Durham Vet Affairs Med Ctr, Dept Surg, Durham, NC USA Univ Illinois, Dept Med, Chicago, IL 60612 USA

Gartel, Andrei L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Med, Chicago, IL 60612 USA Univ Illinois, Dept Med, Chicago, IL 60612 USA
机构:
[1] Univ Illinois, Dept Med, Chicago, IL 60612 USA
[2] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
[3] Durham Vet Affairs Med Ctr, Dept Surg, Durham, NC USA
来源:
关键词:
ARC;
thiazole antibiotics;
melanoma;
Mcl-1;
apoptosis;
FoxM1;
D O I:
10.4161/cc.7.12.6032
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
We previously described the identification of a nucleoside analog transcriptional inhibitor ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-Pyrrolo[2,3-d]-pyrimidine-5-carboxamide) and FoxM1 inhibitor, thiazole antibiotic Siomycin A that were able to induce apoptosis in cancer cell lines of different origin. Here, we report the characterization of these drugs on a panel of melanoma cell lines. We found that in contrast to the common anti-melanoma drug dacarbazine (DTIC), ARC and thiazole antibiotics, Siomycin A and thiostrepton, efficiently inhibited growth and induced cell death in melanoma cell lines in low concentrations. Overexpression of the antiapoptotic protein Mcl-1 protected melanoma cells from apoptosis induced by these compounds. Furthermore, we found that ARC and Siomycin A synergistically induce apoptosis in DM833 melanoma cell line suggesting that they may antagonize different anti-apoptotic pathways in melanoma cells. In general, these drugs may represent important candidates for anti-cancer drug development against melanoma.
引用
收藏
页码:1851 / 1855
页数:5
相关论文
共 21 条
[1]
Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma:: A phase III study
[J].
Avril, MF
;
Aamdal, S
;
Grob, JJ
;
Hauschild, A
;
Mohr, P
;
Bonerandi, JJ
;
Weichenthal, M
;
Neuber, K
;
Bieber, T
;
Gilde, K
;
Porta, VG
;
Fra, J
;
Bonneterre, J
;
Saïag, P
;
Kamanabrou, D
;
Pehamberger, H
;
Sufliarsky, J
;
Larriba, JLG
;
Scherrer, A
;
Menu, Y
.
JOURNAL OF CLINICAL ONCOLOGY,
2004, 22 (06)
:1118-1125

Avril, MF
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Aamdal, S
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Grob, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Hauschild, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Mohr, P
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Bonerandi, JJ
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Weichenthal, M
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Neuber, K
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Bieber, T
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Gilde, K
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Porta, VG
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Fra, J
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Bonneterre, J
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Saïag, P
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Kamanabrou, D
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Pehamberger, H
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Sufliarsky, J
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Larriba, JLG
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Scherrer, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France

Menu, Y
论文数: 0 引用数: 0
h-index: 0
机构: Inst Gustave Roussy, F-94805 Villejuif, France
[2]
Differential sensitivity of human colon cancer cell lines to the nucleoside analogs ARC and DRB
[J].
Bhat, Uppoor G.
;
Gartel, Andrei L.
.
INTERNATIONAL JOURNAL OF CANCER,
2008, 122 (06)
:1426-1429

Bhat, Uppoor G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Med, Chicago, IL 60612 USA Univ Illinois, Dept Med, Chicago, IL 60612 USA

Gartel, Andrei L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Med, Chicago, IL 60612 USA Univ Illinois, Dept Med, Chicago, IL 60612 USA
[3]
Phase III multicenter randomized trial of the dartmouth regimen versus dacarbazine in patients with metastatic melanoma
[J].
Chapman, PB
;
Einhorn, LH
;
Meyers, ML
;
Saxman, S
;
Destro, AN
;
Panageas, KS
;
Begg, CB
;
Agarwala, SS
;
Schuchter, LM
;
Ernstoff, MS
;
Houghton, AN
;
Kirkwood, JM
.
JOURNAL OF CLINICAL ONCOLOGY,
1999, 17 (09)
:2745-2751

Chapman, PB
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Einhorn, LH
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Meyers, ML
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Saxman, S
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Destro, AN
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Panageas, KS
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Begg, CB
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Agarwala, SS
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Schuchter, LM
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Ernstoff, MS
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Houghton, AN
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

Kirkwood, JM
论文数: 0 引用数: 0
h-index: 0
机构: Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[4]
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing bak activation and bax translocation
[J].
Chen, Shuang
;
Dai, Yun
;
Harada, Hisashi
;
Dent, Paul
;
Grant, Steven
.
CANCER RESEARCH,
2007, 67 (02)
:782-791

Chen, Shuang
论文数: 0 引用数: 0
h-index: 0
机构: Virginia Commonwealth Univ, Dept Med, Richmond, VA 23298 USA

Dai, Yun
论文数: 0 引用数: 0
h-index: 0
机构: Virginia Commonwealth Univ, Dept Med, Richmond, VA 23298 USA

Harada, Hisashi
论文数: 0 引用数: 0
h-index: 0
机构: Virginia Commonwealth Univ, Dept Med, Richmond, VA 23298 USA

Dent, Paul
论文数: 0 引用数: 0
h-index: 0
机构: Virginia Commonwealth Univ, Dept Med, Richmond, VA 23298 USA

论文数: 引用数:
h-index:
机构:
[5]
Down-regulation of Mcl-1 by small interfering RNA sensitizes resistant melanoma cells to Fas-mediated apoptosis
[J].
Chetoui, Nizar
;
Sylla, Khaoussou
;
Gagnon-Houde, Jean-Vincent
;
Alcaide-Loridan, Catherine
;
Charron, Dominique
;
Al-Daccak, Reem
;
Aoudjit, Fawzi
.
MOLECULAR CANCER RESEARCH,
2008, 6 (01)
:42-52

Chetoui, Nizar
论文数: 0 引用数: 0
h-index: 0
机构:
CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada
Univ Laval, Fac Med, Quebec City, PQ G1K 7P4, Canada CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada

Sylla, Khaoussou
论文数: 0 引用数: 0
h-index: 0
机构:
Hop St Louis, Inst Univ Hematol, Inst Natl Rech Med Sante U662, St Louis, France CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada

Gagnon-Houde, Jean-Vincent
论文数: 0 引用数: 0
h-index: 0
机构:
CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada
Univ Laval, Fac Med, Quebec City, PQ G1K 7P4, Canada CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada

Alcaide-Loridan, Catherine
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 07, Inst Jacques Monod, F-75251 Paris, France CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada

Charron, Dominique
论文数: 0 引用数: 0
h-index: 0
机构:
Hop St Louis, Inst Univ Hematol, Inst Natl Rech Med Sante U662, St Louis, France CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada

Al-Daccak, Reem
论文数: 0 引用数: 0
h-index: 0
机构:
Hop St Louis, Inst Univ Hematol, Inst Natl Rech Med Sante U662, St Louis, France CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada

Aoudjit, Fawzi
论文数: 0 引用数: 0
h-index: 0
机构:
CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada
Univ Laval, Fac Med, Quebec City, PQ G1K 7P4, Canada CHUQ, Ctr Rech Rhumatol & Immunol, Quebec City, PQ G1V 4G2, Canada
[6]
Cutaneous malignant melanoma
[J].
Cummins, DL
;
Cummins, JM
;
Pantle, H
;
Silverman, MA
;
Leonard, AL
;
Chanmugam, A
.
MAYO CLINIC PROCEEDINGS,
2006, 81 (04)
:500-507

Cummins, DL
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Sch Med, Dept Emergency Med, Baltimore, MD 21287 USA

Cummins, JM
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Sch Med, Dept Emergency Med, Baltimore, MD 21287 USA

Pantle, H
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Sch Med, Dept Emergency Med, Baltimore, MD 21287 USA

Silverman, MA
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Sch Med, Dept Emergency Med, Baltimore, MD 21287 USA

Leonard, AL
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Sch Med, Dept Emergency Med, Baltimore, MD 21287 USA

Chanmugam, A
论文数: 0 引用数: 0
h-index: 0
机构: Johns Hopkins Sch Med, Dept Emergency Med, Baltimore, MD 21287 USA
[7]
Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis
[J].
Eisen, T.
;
Ahmad, T.
;
Flaherty, K. T.
;
Gore, M.
;
Kaye, S.
;
Marais, R.
;
Gibbens, I.
;
Hackett, S.
;
James, M.
;
Schuchter, L. M.
;
Nathanson, K. L.
;
Xia, C.
;
Simantov, R.
;
Schwartz, B.
;
Poulin-Costello, M.
;
O'Dwyer, P. J.
;
Ratain, M. J.
.
BRITISH JOURNAL OF CANCER,
2006, 95 (05)
:581-586

Eisen, T.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Ahmad, T.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Flaherty, K. T.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Gore, M.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Kaye, S.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Marais, R.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Gibbens, I.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Hackett, S.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

James, M.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Schuchter, L. M.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Nathanson, K. L.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Xia, C.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Simantov, R.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Schwartz, B.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Poulin-Costello, M.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

O'Dwyer, P. J.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England

Ratain, M. J.
论文数: 0 引用数: 0
h-index: 0
机构: Royal Marsden Hosp, Urol Unit, Sutton SMT 5PT, Surrey, England
[8]
Melanoma biology and new targeted therapy
[J].
Gray-Schopfer, Vanessa
;
Wellbrock, Claudia
;
Marais, Richard
.
NATURE,
2007, 445 (7130)
:851-857

Gray-Schopfer, Vanessa
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK, Inst Canc Res, Signal Transduct Team, Ctr Cell & Mol Biol, London SW3 6JB, England Canc Res UK, Inst Canc Res, Signal Transduct Team, Ctr Cell & Mol Biol, London SW3 6JB, England

Wellbrock, Claudia
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK, Inst Canc Res, Signal Transduct Team, Ctr Cell & Mol Biol, London SW3 6JB, England Canc Res UK, Inst Canc Res, Signal Transduct Team, Ctr Cell & Mol Biol, London SW3 6JB, England

Marais, Richard
论文数: 0 引用数: 0
h-index: 0
机构:
Canc Res UK, Inst Canc Res, Signal Transduct Team, Ctr Cell & Mol Biol, London SW3 6JB, England Canc Res UK, Inst Canc Res, Signal Transduct Team, Ctr Cell & Mol Biol, London SW3 6JB, England
[9]
Chemosensitisation of malignant melanoma by BCL2 antisense therapy
[J].
Jansen, B
;
Wacheck, V
;
Heere-Ress, E
;
Schlagbauer-Wadl, H
;
Hoeller, C
;
Lucas, T
;
Hoermann, M
;
Hollenstein, U
;
Wolff, K
;
Pehamberger, H
.
LANCET,
2000, 356 (9243)
:1728-1733

Jansen, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria

Wacheck, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria

Heere-Ress, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria

Schlagbauer-Wadl, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria

Hoeller, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria

Lucas, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria

Hoermann, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria

Hollenstein, U
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria

Wolff, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria

Pehamberger, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Vienna, Vienna Gen Hosp, Dept Dermatol, Div Gen Dermatol, A-1090 Vienna, Austria
[10]
Cancer statistics, 2006
[J].
Jemal, A
;
Siegel, R
;
Ward, E
;
Murray, T
;
Xu, JQ
;
Smigal, C
;
Thun, MJ
.
CA-A CANCER JOURNAL FOR CLINICIANS,
2006, 56 (02)
:106-130

Jemal, A
论文数: 0 引用数: 0
h-index: 0
机构:
Amer Canc Soc, Dept Epidemiol & Surveillance Res, Surveillance Informat Serv, Atlanta, GA 30329 USA Amer Canc Soc, Dept Epidemiol & Surveillance Res, Surveillance Informat Serv, Atlanta, GA 30329 USA

Siegel, R
论文数: 0 引用数: 0
h-index: 0
机构: Amer Canc Soc, Dept Epidemiol & Surveillance Res, Surveillance Informat Serv, Atlanta, GA 30329 USA

Ward, E
论文数: 0 引用数: 0
h-index: 0
机构: Amer Canc Soc, Dept Epidemiol & Surveillance Res, Surveillance Informat Serv, Atlanta, GA 30329 USA

Murray, T
论文数: 0 引用数: 0
h-index: 0
机构: Amer Canc Soc, Dept Epidemiol & Surveillance Res, Surveillance Informat Serv, Atlanta, GA 30329 USA

Xu, JQ
论文数: 0 引用数: 0
h-index: 0
机构: Amer Canc Soc, Dept Epidemiol & Surveillance Res, Surveillance Informat Serv, Atlanta, GA 30329 USA

Smigal, C
论文数: 0 引用数: 0
h-index: 0
机构: Amer Canc Soc, Dept Epidemiol & Surveillance Res, Surveillance Informat Serv, Atlanta, GA 30329 USA

Thun, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Amer Canc Soc, Dept Epidemiol & Surveillance Res, Surveillance Informat Serv, Atlanta, GA 30329 USA