Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts

被引：85

作者：

Peterson, Luke F. ^{[1
]}

Boyapati, Anita ^{[1
]}

Ahn, Eun-Young ^{[1
]}

Biggs, Joseph R. ^{[1
]}

Okumura, Akiko Joo ^{[1
]}

Lo, Miao-Chia ^{[1
]}

Yan, Ming ^{[1
]}

Zhang, Dong-Er ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

BLOOD | 2007年 / 110卷 / 03期

关键词：

D O I：

10.1182/blood-2006-11-019265

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosornal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ET0 fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.

引用

页码：799 / 805

页数：7

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