The function role of GATA-3 in Th1 and Th2 differentiation

被引：148

作者：

Zhou, M

Ouyang, W

机构：

[1] Genetech Inc, Dept Immunol, San Francisco, CA 94080 USA

[2] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

来源：

IMMUNOLOGIC RESEARCH | 2003年 / 28卷 / 01期

关键词：

Th1; Th2; GATA-3; cytokines; IFN-gamma; IL-4; transcription factors;

D O I：

10.1385/IR:28:1:25

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

GATA-3 plays a central role in regulating Th1 and Th2 cell differentiation. Upon interleukin (IL)-4 binding to its receptor, GATA-3 is induced through the action of Stat6. GATA-3 regulates Th2 cytokine expression not only at the transcription level, such as directly binding to the promoters of the IL-5 and IL-13 gene, but also by the involvement in the remodeling of the chromatin structure and opening the IL-4 locus. As a master control, GATA-3 stabilizes the Th2 phenotype by two methods. First, GATA-3 shuts down Th1 development through the repression the IL-12 receptor beta2-chain expression. Second, GATA-3 augments its own expression by a positive feedback autoregulation. In this article, we review the recent study of the function of GATA-3 in Th1 and Th2 differentiation.

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页码：25 / 37

页数：13

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