The dopamine transporter: role in neurotoxicity and human disease

被引：94

作者：

Bannon, MJ ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI 48201 USA

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 2005年 / 204卷 / 03期

关键词：

dopamine transporter; neurotoxicity; human disease;

D O I：

10.1016/j.taap.2004.08.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The dopamine transporter (DAT) is a plasma membrane transport protein expressed exclusively within a small subset of CNS neurons. It plays a crucial role in controlling dopamine-mediated neurotransmission and a number of associated behaviors. This review focuses on recent data elucidating the role of the dopamine transporter in neurotoxicity and a number of CNS disorders, including Parkinson disease, drug abuse, and attention deficit hyperactivity disorder (ADHD). (c) 2004 Published by Elsevier Inc.

引用

页码：355 / 360

页数：6

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