CHEMISTRY AND ANTIPROLIFERATIVE ACTIVITIES OF 3-METHOXYFLAVONES ISOLATED FROM Varthemia iphionoides

被引：10

作者：

Al-Dabbas, M. M. ^{[1
]}

Al-Ismail, K. ^{[1
]}

Abu-Taleb, R. ^{[1
]}

Hashimoto, F. ^{[2
,3
]}

Rabah, I. O. ^{[2
,3
]}

Kitahara, K. ^{[2
,3
]}

Fujita, K. ^{[2
,3
]}

Suganuma, T. ^{[2
,3
]}

机构：

[1] Univ Jordan, Fac Agr, Dept Nutr & Food Technol, Amman 11942, Jordan

[2] Kagoshima Univ, Fac Agr, Dept Hort Sci, Kagoshima 8900065, Japan

[3] Kagoshima Univ, Fac Agr, Dept Biochem & Appl Biosci, Kagoshima 8900065, Japan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2011年 / 47卷 / 01期

关键词：

Varthemia iphionoides; 3-methoxyflavone; antiproliferative activity; human leukemia (HL-60) cells; DPPH; SELECTIVE O-ALKYLATION; HL-60; CELLS; FLAVONOIDS; ANTIOXIDANT; DEALKYLATION; APOPTOSIS;

D O I：

10.1007/s10600-011-9821-8

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A new isolated flavone, 4'-hydroxy-3,5,6,7-tetramethoxyflavone (6), together with seven known 3-O-methylated flavones isolated from the ethanol extract of the aerial parts of Varthemia iphionoides, were studied for DPPH free radical-scavenging and cytotoxic activities. Flavones 2, 3, 4, and 8 were the most active DPPH free-radical scavengers with inhibition percentage of 63.5, 42.9, 47.9, and 55.6, respectively, at a concentration of 100 mu g/mL. Flavones 2 and 8 were the most active as inhibitor for human leukemia HL-60 cells; the IC(50) values after 48 h incubation were 20.5 and 23.9 mu g/mL, respectively.

引用

页码：17 / 21

页数：5

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