Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula

被引：56

作者：

Márquez, B

Verdier-Pinard, P

Hamel, E

Gerwick, WH ^{[1
]}

机构：

[1] Oregon State Univ, Coll Pharm, Corvallis, OR 97331 USA

[2] NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag,Dev Therapuet Program, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA

来源：

PHYTOCHEMISTRY | 1998年 / 49卷 / 08期

关键词：

Lyngbya majuscula; Oscillatoriaceae; cyanobacteria; blue-green alga; thiazoline alkaloid; antiproliferative;

D O I：

10.1016/S0031-9422(98)00365-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Curacin D is a novel brine shrimp toxic metabolite isolated from a Virgin Islands collection of the marine cyanobacterium Lyngbya majuscula. Structure elucidation of curacin D was accomplished through multidimensional NMR, GC/MS, and comparisons with curacin A. Curacin D provides new insights into structure-activity relationships iii this natural product class as well as some aspects of the likely biosynthetic pathway of the curacins. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2387 / 2389

页数：3

共 7 条

[1] Biomedical potential of marine natural products [J].