Phosphatidylinositol 3-kinase and the control of endosome dynamics: New players defined by structural motifs

被引：47

作者：

Corvera, S ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01615 USA

来源：

TRAFFIC | 2001年 / 2卷 / 12期

关键词：

FYVE; membrane-traffic; PH-domain; phox; signal-transduction;

D O I：

10.1034/j.1600-0854.2001.21201.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phosphatidylinositol (PtdIns) 3-kinase (PI 3-kinase) activity has been implicated in fundamental cellular functions such as endosomal trafficking, growth-factor receptor signal transduction, and cell survival. This multiplicity of actions can be attributed to the existence of three classes of PI 3-kinases in mammalian cells, which can together lead to the production of four known distinct end products: PtdIns(3)P, PtdIns(3,4)P2, PtdIns(3,4,5)P3 and PtdIns(3,5)P2. The challenge of deciphering the connection between PI 3-kinase activity, the production of specific phosphoinositides and the control of specific cellular events is being met with the discovery of novel structural motifs that interact specifically with distinct PI 3-kinase products.

引用

页码：859 / 866

页数：8

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