Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ

被引：169

作者：

Astry, Brian ^{[1
]}

Venkatesha, Shivaprasad H. ^{[1
]}

Laurence, Arian ^{[2
]}

Christensen-Quick, Aaron ^{[3
]}

Garzino-demo, Alfredo ^{[3
]}

Frieman, Matthew B. ^{[1
]}

O'Shea, John J. ^{[2
]}

Moudgil, Kamal D. ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[2] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA

[3] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA

来源：

CLINICAL IMMUNOLOGY | 2015年 / 157卷 / 02期

关键词：

Celastrol; Chinese medicine; Experimental arthritis; Rheumatoid arthritis; T helper 17 cells; T regulatory cells; Immune regulation; ADJUVANT-INDUCED ARTHRITIS; RHEUMATOID-ARTHRITIS; TH17; CELLS; SUPPRESSES; INHIBITION; MECHANISMS; EXPRESSION; GENERATION; INDUCTION; THERAPY;

D O I：

10.1016/j.clim.2015.01.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Inflammation is an integral component of autoimmune arthritis. The balance of pathogenic T helper 17 (Th17) and protective T regulatory (Treg) cells can influence disease severity, and its resetting offers an attractive approach to control autoimmunity. We determined the frequency of Th17 and Treg in the joints of rats with adjuvant arthritis (AA), a model of rheumatoid arthritis (RA). We also investigated the impact of Celastrol, a bioactive compound from the traditional Chinese medicine Celastrus that can suppress AA, on Th17/Treg balance in the joints. Celastrol treatment reduced Th17 cells but increased Treg in the joints, and it inhibited Th17 differentiation but promoted Treg differentiation in vitro by blocking the activation of pSTAT3. Furthermore, Celastrol limited the production of Th17-differentiating cytokines and chemokines (CCL3, CCL5). Thus, Celastrol suppressed arthritis in part by altering Th17/Treg ratio in inflamed joints, and it should be tested as a potential adjunct/alternative for RA therapy. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：228 / 238

页数：11

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