Asymmetric synthesis of beta-hydroxy sulfones by reduction of chiral beta-keto sulfones

被引：22

作者：

Bernabeu, MC ^{[1
]}

Bonete, P ^{[1
]}

Caturla, F ^{[1
]}

Chinchilla, R ^{[1
]}

Najera, C ^{[1
]}

机构：

[1] UNIV ALICANTE,FAC CIENCIAS,DEPT QUIM ORGAN,ALICANTE 03080,SPAIN

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 09期

关键词：

D O I：

10.1016/0957-4166(96)00310-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral beta-keto sulfones 3 have been prepared from enantiomerically pure sulfinic acids 2 derived from (R)- and S-methylbenzylamine. Enantiospecific reduction of these ketosulfones 3 can be achieved using different hydrides affording beta-hydroxy sulfones. Opposite configurations on the newly created stereocenter is obtained with DIBAL-H or LAH as reducing agents. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2475 / 2478

页数：4

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