Endosome maturation

被引：1793

作者：

Huotari, Jatta ^{[1
]}

Helenius, Ari ^{[1
]}

机构：

[1] ETH, ETH Hoenggerberg, Inst Biochem, CH-8093 Zurich, Switzerland

来源：

EMBO JOURNAL | 2011年 / 30卷 / 17期

基金：

欧洲研究理事会;

关键词：

degradation; endocytosis; intralumenal vesicle (ILV); multivesicular body (MVB); sorting; GTPASE-ACTIVATING PROTEIN; GROWTH-FACTOR RECEPTOR; CLATHRIN-MEDIATED ENDOCYTOSIS; YEAST VACUOLE FUSION; TRANS-GOLGI NETWORK; MULTIVESICULAR BODIES; IN-VITRO; MAMMALIAN-CELLS; ESCRT MACHINERY; PHOSPHATIDYLINOSITOL; 3-KINASE;

D O I：

10.1038/emboj.2011.286

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Being deeply connected to signalling, cell dynamics, growth, regulation, and defence, endocytic processes are linked to almost all aspects of cell life and disease. In this review, we focus on endosomes in the classical endocytic pathway, and on the programme of changes that lead to the formation and maturation of late endosomes/multivesicular bodies. The maturation programme entails a dramatic transformation of these dynamic organelles disconnecting them functionally and spatially from early endosomes and preparing them for their unidirectional role as a feeder pathway to lysosomes. The EMBO Journal (2011) 30, 3481-3500. doi:10.1038/emboj.2011.286

引用

页码：3481 / 3500

页数：20

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