First crystallographic signature of amyloid-like fibril forming β-sheet assemblage from a tripeptide with non-coded amino acids

被引：57

作者：

Maji, SK

Drew, MGB

Banerjee, A ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Biol Chem, Kolkata 700032, W Bengal, India

[2] Univ Whiteknights, Dept Chem, Reading RG6 6AD, Berks, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 19期

关键词：

D O I：

10.1039/b105418j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The model tripeptide Boc-beta -Ala(1)-Aib(2)-beta -Ala(3)-OMe 1 [beta -Ala: beta -alanine, Aib: alpha -aminoisobutyric acid] forms an infinite parallel beta -sheet structure through intermolecular interactions in single crystals and from the SEM diagram of this peptide, it is evident that the compound has fibrillar morphology, a characteristic of neurodegenerative disease causing amyloid aggregate.

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页码：1946 / 1947

页数：2

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