The biological effects of N3-methyladenine

被引：48

作者：

Fronza, G

Gold, B

机构：

[1] Univ Nebraska, Med Ctr, Eppley Inst Res Canc, Omaha, NE 68198 USA

[2] Natl Inst Canc Res, Mutagenesis Lab, I-16132 Genoa, Italy

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2004年 / 91卷 / 02期

关键词：

DNA damage; toxicity; mutagenicity; base excision repair;

D O I：

10.1002/jcb.10698

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The targeting of damage to DNA remains an attractive strategy to kill tumor cells. One of the serious side effects of alkylating agents is that they create both toxic (desired) and mutagenic (undesired) lesions. The result is that patients successfully treated for a primary cancer are at significant risk to develop cancer related to their therapy. To address this issue we have prepared agents that selectively methylate DNA at the N3-position of adenine. The presence of this lesion in DNA is thought to halt DNA polymerase, and this then initiates a cascade of events including cell death. The toxicity and mutagenicity of the compound, Me-lex, used to generate N3-methyladenine is discussed in bacterial, yeast, and mammalian systems. Mechanisms are proposed to explain the biological activities of N3-methyladenine.

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页码：250 / 257

页数：8

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