Treatment of hantavirus pulmonary syndrome

被引：91

作者：

Jonsson, Colleen B. ^{[1
]}

Hooper, Jay ^{[2
]}

Mertz, Gregory ^{[3
]}

机构：

[1] So Res Inst, Dept Biochem & Mol Biol, Birmingham, AL 35205 USA

[2] USA, Med Res Inst Infect Dis, Mol Virol Branch, Ft Detrick, MD 21702 USA

[3] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA

来源：

ANTIVIRAL RESEARCH | 2008年 / 78卷 / 01期

关键词：

hantavirus; HPS; HFRS; hantavirus pulmonary syndrome; bunyavirus; antiviral therapy; ribavirin;

D O I：

10.1016/j.antiviral.2007.10.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Viruses in the genus Hantavirus can cause one of two serious illnesses when transmitted from rodents to humans: hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). Of the two diseases, HPS is more severe with an approximate 40% mortality across the Americas. The high rate of mortality could be reduced if effective therapeutics could be discovered for treatment of this illness. Herein we review approaches being explored for the discovery of therapeutics for HPS and how they could be employed in treatment and preventiom of disease. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：162 / 169

页数：8

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