Galaninergic signalling and adenylate cyclase

被引：21

作者：

Karelson, E

Langel, U ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Labs, Dept Neurochem & Neurotoxicol, S-10691 Stockholm, Sweden

[2] Tartu State Univ, Dept Biochem, EE-202400 Tartu, Estonia

来源：

NEUROPEPTIDES | 1998年 / 32卷 / 03期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1016/S0143-4179(98)90038-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Galanin is a hyperpolarizing, inhibitory neurotransmitter; its recognition by seven transmembrane spanning G-protein-coupled receptors leads to a change in accumulation of cAMP (3'5'-cyclic AMP). Different subtypes of galanin receptor and G-proteins could be manifested in the mode of inhibitory action of galanin receptor on the production of cAMP by adenylate cyclase. Galanin analogues, acting at the adenylate cyclase level as subtype-specific galanin antagonists, can selectively block the inhibitory effect of endogenous galanin and thereby have potential as therapeutic agents for several endocrine, neuroendocrine and neuronal disorders. In this review, the latest results in the field of interplay between galanin-initiated signal transduction and the cAMP pathway are summarized.

引用

页码：197 / 210

页数：14

共 124 条

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