Epstein-Barr virus latent membrane protein 1: Structure and functions

被引：153

作者：

Li, HP ^{[1
]}

Chang, YS ^{[1
]}

机构：

[1] Chang Gung Univ, Grad Inst Basic Med Sci, Taoyuan 333, Taiwan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2003年 / 10卷 / 05期

关键词：

DNA methylation; Epstein-Barr virus; latent membrane protein 1; nasopharyngeal carcinoma; signal transduction;

D O I：

10.1159/000072376

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Epstein-Barr virus latent membrane protein (LMP) 1 is a versatile protein that has profound effects on target cells through its effect on constitutive cellular proteins, e.g. TRAFs, TRADD, RIP, JAK3, BRAM1, and p85. LMP1 can stimulate or inhibit signaling pathways, resulting in transformation of rodent fibroblast cell lines, blockade of differentiation in epithelial cells, upregulation of antiapoptotic proteins, production of cytokines, upregulation of cell surface markers, upregulation of DNA methyltransferase activity, and downregulation of cell adhesion molecules and cyclin-dependent kinases. Overall, this results in greater transformation and survival in LMP1-expressing cells. Within nasopharyngeal carcinoma biopsy tissues, a naturally occurring LMP1 variant has been identified as having a 10-amino acid deletion in the C-terminus that seems to confer greater transformation potential than non-deleted LMP1. The role of LMP1 as a viral oncogene and its interaction with cellular factors are discussed.

引用

页码：490 / 504

页数：15

共 112 条

[71]

Li SN, 1996, ONCOGENE, V12, P2129

[72]

Lu J, 2003, CANCER RES, V63, P256

[73] MAP3K-related kinase involved in NF-kappa B induction by TNF, CD95 and IL-1 [J].

Malinin, NL ;

Boldin, MP ;

Kovalenko, AV ;

Wallach, D .

NATURE, 1997, 385 (6616) :540-544

[74] The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR [J].

Masselink, H ;

Bernards, R .

ONCOGENE, 2000, 19 (12) :1538-1546

[75] Characterization of intercellular adhesion molecule-1 regulation by Epstein-Barr virus-encoded latent membrane protein-1 identifies pathways that cooperate with nuclear factor κB to activate transcription [J].

Mehl, AM ;

Floettmann, JE ;

Jones, M ;

Brennan, P ;

Rowe, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (02) :984-992

[76] Novel intertypic recombinants of Epstein-Barr virus in the Chinese population [J].

Midgley, RS ;

Blake, NW ;

Yao, QY ;

Croom-Carter, D ;

Cheung, ST ;

Leung, SF ;

Chan, ATC ;

Johnson, PJ ;

Huang, D ;

Rickinson, AB ;

Lee, SP .

JOURNAL OF VIROLOGY, 2000, 74 (03) :1544-1548

[77] Epstein-Barr virus LMP1 induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-kappa B activation [J].

Miller, WE ;

Mosialos, G ;

Kieff, E ;

RaabTraub, N .

JOURNAL OF VIROLOGY, 1997, 71 (01) :586-594

[78] STIMULATION OF NF-KAPPA-B-MEDIATED TRANSCRIPTION BY MUTANT DERIVATIVES OF THE LATENT MEMBRANE-PROTEIN OF EPSTEIN-BARR-VIRUS [J].

MITCHELL, T ;

SUGDEN, B .

JOURNAL OF VIROLOGY, 1995, 69 (05) :2968-2976

[79] THE EPSTEIN-BARR-VIRUS TRANSFORMING PROTEIN LMP1 ENGAGES SIGNALING PROTEINS FOR THE TUMOR-NECROSIS-FACTOR RECEPTOR FAMILY [J].

MOSIALOS, G ;

BIRKENBACH, M ;

YALAMANCHILI, R ;

VANARSDALE, T ;

WARE, C ;

KIEFF, E .

CELL, 1995, 80 (03) :389-399

[80] Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells [J].

Murono, S ;

Inoue, H ;

Tanabe, T ;

Joab, I ;

Yoshizaki, T ;

Furukawa, M ;

Pagano, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6905-6910

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