Effects of charge fluctuation on two-membrane instability and fusion

被引：19

作者：

Kim, YW ^{[1
]}

Sung, WK ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Phys, Pohang 790784, South Korea

来源：

PHYSICAL REVIEW LETTERS | 2003年 / 91卷 / 11期

关键词：

D O I：

10.1103/PhysRevLett.91.118101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Membrane fusion is fundamental to diverse biological processes ranging from intercellular and intracellular transport to egg fertilization. We study the effects of coupling between membrane undulation and charge fluctuation on its fusion. We find that, at concentrations of millimolar range, multivalent cations such as calcium in solution induce a strong correlated-charge fluctuation on each membrane, leading to inversion and overcondensation of surface charges. When the charge fluctuation is cooperatively coupled to undulation, two apposing membranes undergo a dynamic instability to spontaneous growth of in-phase undulation with submicron wavelengths, thereby greatly reducing fusion barrier.

引用

页数：4

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