Development of an in vivo tumor-mimic model for learning radiofrequency ablation

被引:56
作者
Scott, DJ
Young, WN
Watumull, LM
Lindberg, G
Fleming, JB
Rege, RV
Brown, RJ
Jones, DB
机构
[1] Univ Texas, SW Med Ctr, Dept Surg, Dallas, TX 75235 USA
[2] Univ Texas, SW Med Ctr, Dept Radiol, Dallas, TX 75235 USA
[3] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75235 USA
关键词
radiofrequency ablation; tumor-mimic; ultrasound; laparoscopy; liver surgery;
D O I
10.1016/S1091-255X(00)80112-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Radiofrequency ablation requires accurate probe placement using ultrasound guidance. The purpose of this study was to develop an in vivo tumor-mimic model fur learning open and laparoscopic radiofrequency ablation. Tumor-mimics were created in ex vivo porcine livers by injecting a mixture of 3% agarose, 3% cellulose, 7% glycerol, and 0.05% methylene blue, which formed 1 cm hyperechoic, discrete lesions on ultrasound. Open and laparoscopic (using a box-trainer) ablation techniques were practiced. Ln vivo experiments were then conducted in 10 pigs. Three tumor-mimics were created in each animal using a laparoscopic approach. Lesions were characterized sonographically, ablated using an open (n = 5) or laparoscopic (n = 5) approach, and examined pathologically. An ablation in normal liver tissue was performed as a control. Tissue impedance was recorded. Target creation took 81 minutes per animal and 96% of injections were successful. Tissue impedance (48.8 +/- 5.8 vs. 49.6 +/- 5.4) and ablation size (25.1 +/- 3.4 vs. 24.3 +/- 5.1) were not significantly different fur controls (n = 8) and tumor-mimics (n = 26), respectively One animal died of a pulmonary embolism following injection of agarose into a hepatic vein. The agarose-based tissue-mimic creates realistic sonographic targets for learning ultrasound-guided open and laparoscopic radiofrequency ablation in an in vivo model.
引用
收藏
页码:620 / 625
页数:6
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