Oncogenic transformation by BK virus and association with human tumors

被引:116
作者
Tognon, M
Corallini, A
Martini, F
Negrini, M
Barbanti-Brodano, G
机构
[1] Univ Ferrara, Dept Expt & Diagnost Med, Microbiol Sect, I-44100 Ferrara, Italy
[2] Univ Ferrara, Dept Morphol & Embryol, Sect Histol & Embryol, I-44100 Ferrara, Italy
[3] Univ Ferrara, Interdept Ctr Canc Res, I-44100 Ferrara, Italy
[4] Univ Ferrara, Ctr Biotechnol, I-44100 Ferrara, Italy
关键词
BK virus; T antigen; transformation; oncogenesis; human tumors;
D O I
10.1038/sj.onc.1206550
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
BK virus (BKV), a human polyomavirus closely related to JC virus and Simian Virus 40, is ubiquitous in human populations worldwide. After primary infection, BKV establishes a lifelong latent infection in many organs. BKV transforms rodent cells to the neoplastic phenotype and is highly oncogenic in rodents. This review considers the oncogenic potential of BKV in humans and its possible involvement in human tumors. BKV sequences and T antigen (Tag) are detected in several types of human neoplasms, although the viral load is generally low, with less than one copy of the viral genome per cell. The possible causative role of BKV in human oncogenesis rests on the ability of BKV Tag to inactivate the functions of tumor suppressor proteins p53 and pRB family as well as on its ability to induce chromosomal aberrations in human cells. A 'hit and run' mechanism and secretion of paracrine growth factors by BKV Tag-positive cells, recruiting into proliferation neighboring and distant cells, are discussed as possible BKV pathogenic elements in human oncogenesis.
引用
收藏
页码:5192 / 5200
页数:9
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