Rhodium-catalyzed addition of aryl boronic acids to 1,2-diketones and 1,2-ketoesters

被引：31

作者：

Ganci, Gregory R. ^{[1
]}

Chisholm, John D. ^{[1
]}

机构：

[1] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 47期

关键词：

D O I：

10.1016/j.tetlet.2007.09.137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The metal complex Rh(acac)(CO)(2) in the presence of dicyclohexylphenylphosphine provides a useful catalyst system for the addition of boronic acids to 1,2-diketones and 1,2-ketoesters. The best yields were obtained when the transformation was performed in DME/H2O at 80 degrees C with 4 equiv of the boronic acid. The results discussed herein extend the scope of the addition of arylboronic acids to highly activated diketones and ketoesters. The products of the reaction are useful in the synthesis of natural products containing oxygenation next to esters or ketones. (C) 2007 Elsevier Ltd. All rights reserved.

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页码：8266 / 8269

页数：4

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