The use of antibodies against the IL-2 receptor in transplantation

被引：109

作者：

Waldmann, TA

O'Shea, J

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

[2] NIAMSD, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(98)80215-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Humanized monoclonal antibodies that recognize the a chain of the IL-2 receptor (e.g. daclizumab) have been used to prevent allograft rejection, since this chain is expressed by T cells participating in allograft rejection but not by resting T cells. In a randomized trial, when added to standard cyclosporin-based immunosuppression, daclizumab significantly reduced the frequency of acute rejection of renal transplants.

引用

页码：507 / 512

页数：6

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