The use of antibodies against the IL-2 receptor in transplantation

被引：109

作者：

Waldmann, TA

O'Shea, J

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

[2] NIAMSD, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(98)80215-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Humanized monoclonal antibodies that recognize the a chain of the IL-2 receptor (e.g. daclizumab) have been used to prevent allograft rejection, since this chain is expressed by T cells participating in allograft rejection but not by resting T cells. In a randomized trial, when added to standard cyclosporin-based immunosuppression, daclizumab significantly reduced the frequency of acute rejection of renal transplants.

引用

页码：507 / 512

页数：6

共 66 条

[61] RADIOIMMUNOTHERAPY OF INTERLEUKIN-2R-ALPHA-EXPRESSING ADULT T-CELL LEUKEMIA WITH YTTRIUM-90-LABELED ANTI-TAC [J].

WALDMANN, TA ;

WHITE, JD ;

CARRASQUILLO, JA ;

REYNOLDS, JC ;

PAIK, CH ;

GANSOW, OA ;

BRECHBIEL, MW ;

JAFFE, ES ;

FLEISHER, TA ;

GOLDMAN, CK ;

TOP, LE ;

BAMFORD, R ;

ZAKNOEN, S ;

ROESSLER, E ;

KASTENSPORTES, C ;

ENGLAND, R ;

LITOU, H ;

JOHNSON, JA ;

JACKSONWHITE, T ;

MANNS, A ;

HANCHARD, B ;

JUNGHANS, RP ;

NELSON, DL .

BLOOD, 1995, 86 (11) :4063-4075

[62]

WALDMANN TA, 1991, J BIOL CHEM, V266, P2681

[63] THE IL-2/IL-2 RECEPTOR SYSTEM - A TARGET FOR RATIONAL IMMUNE INTERVENTION (REPRINTED FROM TRENDS IN PHARMACOLOGICAL SCIENCES, VOL 14, PG 159-164, 1993) [J].

WALDMANN, TA .

IMMUNOLOGY TODAY, 1993, 14 (06) :264-270

[64]

WALDMANN TA, 1988, BLOOD, V72, P1805

[65] INVOLVEMENT OF THE JAK-3 JANUS KINASE IN SIGNALING BY INTERLEUKIN-2 AND INTERLEUKIN-4 IN LYMPHOID AND MYELOID CELLS [J].

WITTHUHN, BA ;

SILVENNOINEN, O ;

MIURA, O ;

LAI, KS ;

CWIK, C ;

LIU, ET ;

IHLE, JN .

NATURE, 1994, 370 (6485) :153-157

[66] SPECIFIC TOLERANCE TO NEURAL ALLOGRAFTS INDUCED WITH AN ANTIBODY TO THE INTERLEUKIN-2 RECEPTOR [J].

WOOD, MJA ;

SLOAN, DJ ;

DALLMAN, MJ ;

CHARLTON, HM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (03) :597-603

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