A candidate taste receptor gene near a sweet taste locus

被引：357

作者：

Montmayeur, JP ^{[1
]}

Liberles, SD ^{[1
]}

Matsunami, H ^{[1
]}

Buck, LB ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Neurobiol, Boston, MA 02115 USA

来源：

NATURE NEUROSCIENCE | 2001年 / 4卷 / 05期

基金：

日本学术振兴会; 美国国家卫生研究院;

关键词：

D O I：

10.1038/87440

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mechanisms underlying sweet taste in mammals have been elusive. Although numerous studies have implicated G proteins in sweet taste detection, the expected G protein-coupled receptors have not been found. Here we describe a candidate taste receptor gene, T1r3, that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet tastants. T1R3 differs in amino acid sequence in mouse strains with different Sac phenotypes ('tasters' versus 'nontasters'). In addition, a perfect correlation exists between two different T1r3 alleles and Sac phenotypes in recombinant inbred mouse strains. The T1r3 gene is expressed in a subset of taste cells in circumvallate, foliate and fungiform taste papillae. In circumvallate and foliate papillae, most T1r3-expressing cells also express a gene encoding a related receptor, T1R2 raising the possibility that these cells recognize more than one ligand, or that the two receptors function as heterodimers.

引用

页码：492 / 498

页数：7

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