Free recombination within Helicobacter pylori

被引：474

作者：

Suerbaum, S

Smith, JM

Bapumia, K

Morelli, G

Smith, NH

Kunstmann, E

Dyrek, I

Achtman, M ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Dept Med Microbiol, D-44780 Bochum, Germany

[2] Univ Sussex, Sch Biol Sci, Brighton BN1 9QG, E Sussex, England

[3] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

[4] Ruhr Univ Bochum, Dept Internal Med, Knappschafts Krankenhaus, D-44892 Bochum, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 21期

基金：

英国惠康基金;

关键词：

nucleotide sequencing; horizontal genetic exchange; evolution; linkage equilibrium;

D O I：

10.1073/pnas.95.21.12619

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage equilibrium by using the Homoplasy Test and compatibility matrices. Horizontal genetic exchange in H. pylori is so frequent that different loci and polymorphisms within each locus are all at linkage equilibrium. These results indicate that H, pylori is panmictic, Comparisons with sequences from Escherichia coli, Neisseria meningitidis, and Drosophila melanogaster showed that recombination in H, pylori was much more frequent than in other species. In contrast, when multiple family members infected with H, pylori were investigated, some strains were indistinguishable at all three loci. Thus, H, pylori is clonal over short time periods after natural transmission.

引用

页码：12619 / 12624

页数：6

共 44 条

[11]

DUNCAN KE, 1994, EVOLUTION, V48, P2002, DOI 10.1111/j.1558-5646.1994.tb02229.x

[12]

DYKHUIZEN D, 1992, ENCY MICROBIOLOGY, P351

[13] ANALYSIS OF GENETIC DIVERSITY IN CYTOTOXIN-PRODUCING AND NON-CYTOTOXIN-PRODUCING HELICOBACTER-PYLORI STRAINS [J].