Peering through the pore: Nuclear pore complex structure, assembly, and function

被引：345

作者：

Suntharalingam, M ^{[1
]}

Wente, SR ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Nashville, TN 37232 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1016/S1534-5807(03)00162-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear pore complexes (NPCs) are large protein-aceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus and cytoplasm. This includes the movement of small molecules and the selective, facilitated transport of large proteins and RNAs. Faithful, continuous NPC assembly is key for maintaining normal physiological function and is closely tied to proper cell division. This review focuses on the most outstanding issues involving NPC structure, assembly, and function.

引用

页码：775 / 789

页数：15

共 164 条

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