Peering through the pore: Nuclear pore complex structure, assembly, and function

被引：345

作者：

Suntharalingam, M ^{[1
]}

Wente, SR ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Nashville, TN 37232 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1016/S1534-5807(03)00162-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear pore complexes (NPCs) are large protein-aceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus and cytoplasm. This includes the movement of small molecules and the selective, facilitated transport of large proteins and RNAs. Faithful, continuous NPC assembly is key for maintaining normal physiological function and is closely tied to proper cell division. This review focuses on the most outstanding issues involving NPC structure, assembly, and function.

引用

页码：775 / 789

页数：15

共 164 条

[61] Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores [J].

Harel, A ;

Orjalo, AV ;

Vincent, T ;

Lachish-Zalait, A ;

Vasu, S ;

Shah, S ;

Zimmerman, E ;

Elbaum, M ;

Forbes, DJ .

MOLECULAR CELL, 2003, 11 (04) :853-864

[62] Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control [J].

Hediger, F ;

Dubrana, K ;

Gasser, SM .

JOURNAL OF STRUCTURAL BIOLOGY, 2002, 140 (1-3) :79-91

[63] GTP hydrolysis by Ran is required for nuclear envelope assembly [J].

Hetzer, M ;

Bilbao-Cortés, D ;

Walther, TC ;

Gruss, OJ ;

Mattaj, IW .

MOLECULAR CELL, 2000, 5 (06) :1013-1024

[64] Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly [J].

Hetzer, M ;

Meyer, HH ;

Walther, TC ;

Bilbao-Cortes, D ;

Warren, G ;

Mattaj, IW .

NATURE CELL BIOLOGY, 2001, 3 (12) :1086-1091

[65] The production of 'cell cortices' for light and electron microscopy [J].

Heuser, J .

TRAFFIC, 2000, 1 (07) :545-552

[66] ARCHITECTURE AND DESIGN OF THE NUCLEAR-PORE COMPLEX [J].

HINSHAW, JE ;

CARRAGHER, BO ;

MILLIGAN, RA .

CELL, 1992, 69 (07) :1133-1141

[67] The integral membrane protein Snl1p is genetically linked to yeast nuclear pore complex function [J].

Ho, AK ;

Raczniak, GA ;

Ives, EB ;

Wente, SR .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (02) :355-373

[68] The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98 [J].

Hodel, AE ;

Hodel, MR ;

Griffis, ER ;

Hennig, KA ;

Ratner, GA ;

Xu, SL ;

Powers, MA .

MOLECULAR CELL, 2002, 10 (02) :347-358

[69] Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells [J].

Hodge, CA ;

Colot, HV ;

Stafford, P ;

Cole, CN .

EMBO JOURNAL, 1999, 18 (20) :5778-5788

[70] Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins [J].

Hu, TH ;

Guan, TL ;

Gerace, L .

JOURNAL OF CELL BIOLOGY, 1996, 134 (03) :589-601

← 2 3 4 5 6 7 8 9 10 11 →