The adverse effects of maternal smoking on the human placenta: A review

被引:171
作者
Zdravkovic, T
Genbacev, O
McMaster, MT
Fisher, SJ
机构
[1] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Pharmaceut Chem & Anat, San Francisco, CA 94143 USA
关键词
tobacco; nicotine; placenta; trophoblast; VHL; HIFs; hypoxia; pregnancy;
D O I
10.1016/j.placenta.2005.02.003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Studies of placental pathologies associated with maternal cigarette smoking have led to many interesting observations. For example, maternal smoking impairs human placental development by changing the balance between cytotrophoblast (CTB) proliferation and differentiation. It is likely that chronic exposure to tobacco constituents in early pregnancy can affect placental development directly or indirectly by reducing blood flow, which creates a pathologically hypoxic environment. To understand this process at a molecular level, tissue samples from non-smoking and smoking mothers were studied to determine whether active and/or passive cigarette smoke exposure affects CTB expression of molecules that govern cellular responses to oxygen tension: the von Hippel-Lindau tumor suppressor protein (pVHL), hypoxia-inducible transcription factors (HIFs) and vascular endothelial growth factor-A (VEGF). The results show that maternal smoking dysregulates CTB expression of all three types of molecules. In addition, cell columns and proliferating cells were reduced while there was a corresponding increase in cell islands. All three phenomena were most obvious in the placentas of heavy smokers. Interestingly, a subset of the aforementioned effects can be detected in samples obtained from women who were passively exposed to cigarette smoke during pregnancy. These observations suggest that tobacco constituents exert direct effects on CTB proliferation and differentiation and help to explain the mechanisms by which smoking negatively effects human pregnancy outcome. (c) 2005 Published by IFPA and Elsevier Ltd.
引用
收藏
页码:S81 / S86
页数:6
相关论文
共 60 条
[31]   Preterm birth and maternal smoking: Risks related to gestational age and onset of delivery [J].
Kyrklund-Blomberg, NB ;
Cnattingius, S .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1998, 179 (04) :1051-1055
[32]   The maternal and fetal physiologic effects of nicotine [J].
Lambers, DS ;
Clark, KE .
SEMINARS IN PERINATOLOGY, 1996, 20 (02) :115-126
[33]   Stereologic examination of placentas from mothers who smoke during pregnancy [J].
Larsen, LG ;
Clausen, HV ;
Jonsson, L .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2002, 186 (03) :531-537
[34]   92-KD TYPE-IV COLLAGENASE MEDIATES INVASION OF HUMAN CYTOTROPHOBLASTS [J].
LIBRACH, CL ;
WERB, Z ;
FITZGERALD, ML ;
CHIU, K ;
CORWIN, NM ;
ESTEVES, RA ;
GROBELNY, D ;
GALARDY, R ;
DAMSKY, CH ;
FISHER, SJ .
JOURNAL OF CELL BIOLOGY, 1991, 113 (02) :437-449
[35]   Moderate smoking during pregnancy is associated with a reduced risk of preeclampsia [J].
Lindqvist, PG ;
Marsál, K .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1999, 78 (08) :693-697
[36]   von Hippel-Lindau disease [J].
Maher, ER ;
Kaelin, WG .
MEDICINE, 1997, 76 (06) :381-391
[37]  
Mathews T J, 2002, Natl Vital Stat Rep, V50, P1
[38]   CIGARETTE-SMOKING AT TIME OF IN-VITRO FERTILIZATION CYCLE INITIATION HAS NEGATIVE EFFECT ON IN-VITRO FERTILIZATION-EMBRYO TRANSFER SUCCESS RATE [J].
MAXIMOVICH, A ;
BEYLER, SA .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1995, 12 (02) :75-77
[39]   Patterns of villous and intervillous space growth in human placentas from normal and abnormal pregnancies [J].
Mayhew, TM .
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1996, 68 (1-2) :75-82
[40]   Cocaine and tobacco use and the risk of spontaneous abortion [J].
Ness, RB ;
Grisso, JA ;
Hirschinger, N ;
Markovic, N ;
Shaw, LM ;
Day, NL ;
Kline, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (05) :333-339